What is it about?
By using the 10BASEd-T, here we demonstrate a novel concept of construction of a supramolecule candidate (i.e. crown ether analog) library with vast diversity by randomizing peptide linker around the diazacoronand core.
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Why is it important?
By the artificial-molecule evolution via the 10BASEd-T, we cou find non-natural targe-specific binders. From the crown library, we could successfully discovered the target-protein specific binder as a potential drug candidate. As the target protein, we used a molecular chaperone Hsp90. It is one of the hottest protein because many cancers and diseases are related to it.
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This page is a summary of: Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7, Chemical Communications, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c4cc00811a.
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