Tripodal molecules for the promotion of phosphoester hydrolysis

Jennifer R. Hiscock, Mark R. Sambrook, Philippa B. Cranwell, Pat Watts, Jack C. Vincent, David J. Xuereb, Neil J. Wells, Robert Raja, Philip A. Gale
  • Chemical Communications, January 2014, Royal Society of Chemistry
  • DOI: 10.1039/c4cc00333k

Towards organocatalysts for nerve agent remediation

What is it about?

We are developing organic molecules that speed up the hydrolysis of nerve agents such as soman. In this first paper we show that tripodal molecules containing histidine groups accelerate the rate of hydrolysis.

Why is it important?

We're working on new ways both to detect and to destroy nerve agents. This paper shows how simple organic molecules can speed up the reaction of nerve agents with water.

Read Publication

http://dx.doi.org/10.1039/c4cc00333k

The following have contributed to this page: Professor Philip Gale

In partnership with: