X-ray-amorphous calcium phosphate (ACP) synthesis in a simple biomineralization medium

A. Cuneyt Tas
  • Journal of Materials Chemistry B, January 2013, Royal Society of Chemistry
  • DOI: 10.1039/c3tb20854k

Amorphous calcium phosphate (ACP) nanosphere synthesis and ACP coating on substrates

What is it about?

Amorphous calcium phosphate (ACP) is similar to the inorganic phase of the fontanelles of new-born babies. ACP is usually the first inorganic phase to form in any calcium phosphate synthesis. That first-forming ACP may then undergo a process of maturation to transform itself into the bone mineral. This study discloses a simple-to-prepare solution to serve two different purposes: (1) to synthesize non-agglomerated nanospheres of ACP, (2) to coat the surfaces of materials with a layer of ACP.

Why is it important?

The synthesis of monodisperse nanospheres of amorphous calcium phosphate (ACP) was not possible, prior to this study, without adding significant concentrations of man-made and water-soluble organics into the synthesis media. The novel biocompatible solution described in this article does not need any of such organics to form those ACP nanospheres. Monodisperse ACP nanospheres are potential carrier candidates for the delivery of genes, drugs and bioactive molecules within the human body.

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