What is it about?
Amorphous calcium phosphate (ACP) is similar to the inorganic phase of the fontanelles of new-born babies. ACP is usually the first inorganic phase to form in any calcium phosphate synthesis. That first-forming ACP may then undergo a process of maturation to transform itself into the bone mineral. This study discloses a simple-to-prepare solution to serve two different purposes: (1) to synthesize non-agglomerated nanospheres of ACP, (2) to coat the surfaces of materials with a layer of ACP.
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Why is it important?
The synthesis of monodisperse nanospheres of amorphous calcium phosphate (ACP) was not possible, prior to this study, without adding significant concentrations of man-made and water-soluble organics into the synthesis media. The novel biocompatible solution described in this article does not need any of such organics to form those ACP nanospheres. Monodisperse ACP nanospheres are potential carrier candidates for the delivery of genes, drugs and bioactive molecules within the human body.
Read the Original
This page is a summary of: X-ray-amorphous calcium phosphate (ACP) synthesis in a simple biomineralization medium, Journal of Materials Chemistry B, January 2013, Royal Society of Chemistry,
DOI: 10.1039/c3tb20854k.
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Resources
ACP nanospheres forming in an inorganic, DMEM-like solution
ACP nanospheres forming in a DMEM-like, yet purely inorganic solution, when that solution is only stirred at 65 C in a glass beaker
Glass slides coated with ACP
Glass slides being coated with quite a uniform layer of ACP nanoparticles, upon simple immersion at 37 C in that inorganic, DMEM-like solution
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