What is it about?
High molecular weight (Mw 1x10+6 Da) hyaluronic acid (HA) interacts via hydrogen bonds with the headgroups of the polar lipids of human meibum (hMGS), the major constituent of tear film lipid layer (TFLL). The spreading and dilatational elasticity of hMGS surface films are enhanced. Thus non-surface active molecules like HA and tear secretory mucins can regulate TFLL performance. The anionic HA captures the cationic C12-BAC in bulk complexes unable to penetrate and damage hMGS films.
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Why is it important?
A mechanism is revealed how the sugar moieties of secretory mucins, the major tear polymers, can regulate the performance of tear film lipid layer. Our study suggests a possible novel implementation of anionic polyelectrolytes like HA to ophthalmic drug delivery systems: the polymers can be instilled on the ocular surface together with cationic surfactant containing drugs and increase the biocompatibility of the formulations.
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This page is a summary of: Surface chemistry study of the interactions of hyaluronic acid and benzalkonium chloride with meibomian and corneal cell lipids, Soft Matter, January 2013, Royal Society of Chemistry,
DOI: 10.1039/c3sm51849c.
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