What is it about?
The most unique point: 3'-guanine was specifically oxidized in quadruplex DNA, which depended on the localization of the HOMO. In single- or double-stranded DNA, the specific oxidation at 3'-guanine has never been observed.
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Why is it important?
Many important guanine-rich oligonucleotides can form quadruplex structure, and the quadruplex stability influences the telomere elongation by telomerase and the transcription activity of c-myc. Therefore, we will investigate the relation between this specific oxidation and the stability of quadruplex DNA.
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This page is a summary of: Product analysis of photooxidation in isolated quadruplex DNA; 8-oxo-7,8-dihydroguanine and its oxidation product at 3′-G are formed instead of 2,5-diamino-4H-imidazol-4-one, RSC Advances, January 2013, Royal Society of Chemistry,
DOI: 10.1039/c3ra44290j.
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