Immunotoxicity of nanoparticles: a computational study suggests that CNTs and C60 fullerenes might be recognized as pathogens by Toll-like receptors

M. Turabekova, B. Rasulev, M. Theodore, J. Jackman, D. Leszczynska, J. Leszczynski
  • Nanoscale, January 2014, Royal Society of Chemistry
  • DOI: 10.1039/c3nr05772k

Toll-like receptors recognize CNTs and C60 fullerenes as pathogens, activate immune protection

What is it about?

We suggest a hypothetical model providing the potential mechanistic explanation for immune and inflammatory responses observed upon exposure to carbon nanoparticles. Both CNT and fullerene induce, in cells, secretion of certain inflammatory protein mediators, such as interleukins and chemokines. These proteins are observed within inflammation downstream processes resulted from ligand molecule dependent inhibition or activation of TLRs –induced signal transduction. Our computational studies have shown that the internal hydrophobic pockets of some TLRs might be capable to bind small-sized carbon nanostructures, CNTs and C60 fullerenes.

Why is it important?

A first study that suggests CNTs and fullerenes induce immune reaction by interaction with TLR receptors.

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The following have contributed to this page: Professor Bakhtiyor Rasulev and Professor Jerzy Leszczynski