Silica–F127 nanohybrid-encapsulated manganese oxide nanoparticles for optimized T1magnetic resonance relaxivity

Benedict You Wei Hsu, Miao Wang, Yu Zhang, Vimalan Vijayaragavan, Siew Yee Wong, Alex Yuang-Chi Chang, Kishore Kumar Bhakoo, Xu Li, John Wang
  • Nanoscale, January 2014, Royal Society of Chemistry
  • DOI: 10.1039/c3nr04378a

What is it about?

To properly engineer MnO nanoparticles of high r1 relaxivity, a nanohybrid coating consisting of silica and F127 is designed to encapsulate MONPs. Achieved by an interfacialtemplating scheme, the nanohybrid encapsulating layer is highly permeable and hydrophilic to allow foran optimal access of water molecules to the encapsulated manganese oxide core. Hence, the efficacy as MRI contrast agents is significantly improved, as demonstrated by an enhancement of the MR signal.

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The following have contributed to this page: Xu Li