What is it about?
Previous studies have shown that the severe toxic side effects of cisplatin can be mitigated by d-methionine. We have employed a metallomics approach to demonstrate that the relevant interaction unfolds in blood plasma. Based on the structural characterization of the d-methionine-platinum adduct, we propose a feasible biochemical mechanism of its formation.
Featured Image
Why is it important?
These results are import because they open the door to mitigate the toxic side effects of cisplatin, while maintaining its anticancer efficiency.
Read the Original
This page is a summary of: Chemoprotection byd-methionine against cisplatin-induced side-effects: insight from in vitro studies using human plasma, Metallomics, January 2014, Oxford University Press (OUP),
DOI: 10.1039/c3mt00238a.
You can read the full text:
Contributors
The following have contributed to this page
