Mitigating Cd bioaccummulation in human tissues

What is it about?

The Cd concentration in human tissues increases with age, but there is no effective chelating agent which can enhance its excretion. One major problem that has to be over come is the lack of selectivity of chelating agents, which manifests itself by the chelating agent adversely affecting the metabolism of essential elements. We show that this problem can be overcome by administering the Zn-salt of the chelating agent.

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Why is it important?

These findings are important because by injecting a patient with the Zn-salt of DTPA one can entirely prevent adverse effects of the chelating agent on the Zn-metabolism, which is a common side-effect side effect.