square planar Cu(II) complexes from benzamide derivatives with cytotoxicity against five cancers

What is it about?

This paper explains the synthesis of benzamide derivatives from many simple compounds. These derivatives react with cu(II) ion and are oxidized to the other benzamide derivatives. This oxidation is done with removal of two hydrogens and formation of a five membered ring. These new derivatives as ligands can be coordinated to Cu(II) ion and make a rare square planar structure around Cu(II) ion. In vitro these ligands and their complexes showed cytotoxicity against five human cancer cell lines.

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Why is it important?

-Preparation of benzamide derivatives are very simple. -Their oxidation are very fast and simple with high yield. -The complexes have the square planar structures that they are very rare. - Complexes and ligands show cytotoxic activity against some human cancer cell lines, but this activity in complexes is more than their ligands.