Racemic marinopyrrole B by total synthesis

Ping Cheng, Derrick L. J. Clive, Shimal Fernandopulle, Zhenhua Chen
  • Chemical Communications, January 2013, Royal Society of Chemistry
  • DOI: 10.1039/c2cc37110c

Synthesis of the marine natural product antibiotic marinopyrrole B.

What is it about?

Marinopyrrole B is an antibiotic of unusual structure. The structure presents some difficult challenges for synthesis and a method to overcome the challenges was developed.

Why is it important?

Marinopyrrole is active against methicillin-resistant bacteria and the core structure may represent a new pharmacophore for the design of other antibiotics.

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