Squalene–hopene cyclase: catalytic mechanism and substrate recognition

Tsutomu Hoshino, Tsutomu Sato
  • Chemical Communications, January 2002, Royal Society of Chemistry
  • DOI: 10.1039/b108995c

Squalene-hopene cyclase:catalytic mechanism and substrate recogniton

What is it about?

This review describes the cyclization mechanism of squalene into pentacyclic triterpenes, hopene and hopanol.

Why is it important?

For long times. many eminent chemists have engaged in the studies of how acyclic squalene molecule is cyclized into cyclic triterpene, especially focused on the stereochemistry . However, the mechanism using the enzyme has not been carried out. This review has introduced the enzymatic mechanism by bacterial triterpene cyclase


Tsutomu Hoshino
Niigata University

This review will be a leading paper for all the chemists and biochemists investigating triterpene biosyntheses.

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