Squalene-hopene cyclase:catalytic mechanism and substrate recogniton

What is it about?

This review describes the cyclization mechanism of squalene into pentacyclic triterpenes, hopene and hopanol.

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Why is it important?

For long times. many eminent chemists have engaged in the studies of how acyclic squalene molecule is cyclized into cyclic triterpene, especially focused on the stereochemistry . However, the mechanism using the enzyme has not been carried out. This review has introduced the enzymatic mechanism by bacterial triterpene cyclase

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