What is it about?
Herein we demonstrate the first example of oligonucleotide templated reaction (OTR) performed on paper, using lateral flow assays for amplification-free detection of circulating miRNA (miR-150-5p), a recently identified predictive blood biomarker for preterm birth.
Photo by Hush Naidoo on Unsplash
Why is it important?
The majority of preterm births (PTBs) are to women with no identifiable risk factors, making cases extremely hard to predict at an early stage, when the mother would benefit the most from medical treatment. Low-cost, paper-based blood tests for early prediction of PTB could provide a valuable alternative to current approaches that could improve neonatal outcomes.
Read the Original
This page is a summary of: Oligonucleotide-templated lateral flow assays for amplification-free sensing of circulating microRNAs, Chemical Communications, January 2019, Royal Society of Chemistry, DOI: 10.1039/c9cc05607f.
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