Diketopyrrolopyrrole-based carbon dots for photodynamic therapy

Haozhe He, Xiaohua Zheng, Shi Liu, Min Zheng, Zhigang Xie, Yong Wang, Meng Yu, Xintao Shuai
  • Nanoscale, January 2018, Royal Society of Chemistry
  • DOI: 10.1039/c8nr02643b

Diketopyrrolopyrrole-based carbon dots for photodynamic therapy

What is it about?

The development of a simple and straightforward strategy to synthesize multifunctional carbon dots for photodynamic therapy (PDT) has been an emerging focus. In this work, diketopyrrolopyrrole-based fluorescent carbon dots (DPP CDs) were designed and synthesized through a facile one-pot hydrothermal method by using diketopyrrolopyrrole (DPP) and chitosan (CTS) as raw materials. DPP CDs not only maintained the ability of DPP to generate singlet oxygen (1O2) but also have excellent hydrophilic properties and outstanding biocompatibility. In vitro and in vivo experiments demonstrated that DPP CDs greatly inhibited the growth of tumor cells under laser irradiation (540 nm). This study highlights the potential of the rational design of CDs for efficient cancer therapy.

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http://dx.doi.org/10.1039/c8nr02643b

The following have contributed to this page: Xiaohua Zheng