Efficient intracellular delivery of biomacromolecules employing clusters of zinc oxide nanowires

Prashant Sharma, Hyun Ah Cho, Jae-Won Lee, Woo Seung Ham, Bum Chul Park, Nam-Hyuk Cho, Young Keun Kim
  • Nanoscale, January 2017, Royal Society of Chemistry
  • DOI: 10.1039/c7nr05219g

ZnO Nanowire Cell interaction and toxicity

What is it about?

The Interaction of ZnO Nanowire in two conformations with cells in the context of morphological charges, cell growth pattern, toxicity, and cell uptake was studied in this article. Mechanism of how cells are taking up the biomolecules attached on the nanowires has also been described.

Why is it important?

We found that different conformation of nanowires interacting very differently with cells. The two different physical conformations, vertical (VNW) or fan-shaped (FNW) nanowires have no difference in toxicity and cell growth, but cells are forming lamellipodia to wrap FNW. There is also a significant difference in endocytosis and penetration, which is also visible at the time of DNA transfection.

Perspectives

prashant sharma (Author)
Seoul National University

that ZnO nanowires (NWs) can efficiently deliver associated biomacromolecules, including peptides and DNA, into eukaryotic cells when in the appropriate 3-dimensional dimensional conformation with tolerable toxicity.

Read Publication

http://dx.doi.org/10.1039/c7nr05219g

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