Tandem deprotection/coupling for peptide synthesis in water at room temperature

Margery Cortes-Clerget, Jean-Yves Berthon, Isabelle Krolikiewicz-Renimel, Laurent Chaisemartin, Bruce H. Lipshutz
  • Green Chemistry, January 2017, Royal Society of Chemistry
  • DOI: 10.1039/c7gc01575e

Peptide synthesis in water

What is it about?

While peptide synthesis is mostly performed in toxic solvents, we propose an environmentally friendly alternative, in water, at room temperature. 2 steps can be performed in 1-pot, to make the process even greener.

Why is it important?

The purpose is to get organic solvent out of peptide synthesis, to address health and environmental issues.

Perspectives

Margery Cortes-Clerget (Author)
University of California, Santa Barbara

This method is not only a “replacement” of solvents. The hydrophobic effect created by the micellar media helps the reaction to proceed faster. In some cases, micellar catalysis succeeded when organic solvents failed.

Read Publication

http://dx.doi.org/10.1039/c7gc01575e

The following have contributed to this page: Margery Cortes-Clerget