Tandem deprotection/coupling for peptide synthesis in water at room temperature

Margery Cortes-Clerget, Jean-Yves Berthon, Isabelle Krolikiewicz-Renimel, Laurent Chaisemartin, Bruce H. Lipshutz
  • Green Chemistry, January 2017, Royal Society of Chemistry
  • DOI: 10.1039/c7gc01575e

Peptide synthesis in water

What is it about?

While peptide synthesis is mostly performed in toxic solvents, we propose an environmentally friendly alternative, in water, at room temperature. 2 steps can be performed in 1-pot, to make the process even greener.

Why is it important?

The purpose is to get organic solvent out of peptide synthesis, to address health and environmental issues.


Margery Cortes-Clerget (Author)
University of California, Santa Barbara

This method is not only a “replacement” of solvents. The hydrophobic effect created by the micellar media helps the reaction to proceed faster. In some cases, micellar catalysis succeeded when organic solvents failed.

Read Publication


The following have contributed to this page: Margery Cortes-Clerget