Study of the interaction between cisplatin and the Au18(SR)14 cluster: in search of an appropriate cisplatin carrier

  • O. Palacios-Álvarez, A. Tlahuice-Flores
  • Physical Chemistry Chemical Physics, January 2017, Royal Society of Chemistry
  • DOI: 10.1039/c7cp04452f

Thiolated Au18 cluster as a cisplatin carrier

What is it about?

Thiolated Au18 cluster is bio-compatible and it has demonstrated that is able to adsorb cisplatin molecule(s). The calculated adsorption energy is comprised in the 0.5 - 3.6 eV range and it opens up a new direction into the thiolated gold cluster potential applications

Why is it important?

The cisplatin is a well known anticancer drug but unfortunately it features side effects due to its loss during it transit toward affected organs or tissues. Our goal is to provide with a nano-carrier able to "transport" cisplatin maintaining cisplatin integrity (amount and structure).

Perspectives

Dr Alfredo Tlahuice
University Autonomous Nuevo Leon

In the meantime we hope our study might encourage to experimentalist to confirm our computational prediction. This kind of studies will result in a new direction in the search of applications of thiolated gold clusters

Read Publication

http://dx.doi.org/10.1039/c7cp04452f

The following have contributed to this page: Dr Alfredo Tlahuice