Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation

Chao Liu, Xin Cui, Thomas M. Ackermann, Vittoria Flamini, Weiqiang Chen, Alesha B. Castillo
  • Integrative Biology, January 2016, Royal Society of Chemistry
  • DOI: 10.1039/c6ib00070c

What is it about?

Angiogenesis, the generation of new blood vessels from existing vessels, plays an important role in skeletal health. We have shown that bone cells release factors, or "osteokines", that can regulate the growth of new blood vessels.

Why is it important?

We show that bone cells release factors, or "osteokines", that regulate angiogenesis in response to mechanical stimulation. Our data indicate that in vivo mechanical loading (e.g., weight bearing, walking, running) may regulate new blood vessel formation, which is critical for normal bone homeostasis and regeneration. A better understanding of the signaling pathways contributing to "osteo-angio" crosstalk may reveal important new pharmacological targets to prevent and treat osteoporosis, disuse bone loss, and traumatic bone fracture.

Perspectives

Dr Alesha B Castillo (Author)
New York University

We believe that "osteokines" play an important role in skeletal health through regulation of homeostasis, regeneration, and repair.

Read Publication

http://dx.doi.org/10.1039/c6ib00070c

The following have contributed to this page: Dr Alesha B Castillo

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