What is it about?
Angiogenesis, the generation of new blood vessels from existing vessels, plays an important role in skeletal health. We have shown that bone cells release factors, or "osteokines", that can regulate the growth of new blood vessels.
Why is it important?
We show that bone cells release factors, or "osteokines", that regulate angiogenesis in response to mechanical stimulation. Our data indicate that in vivo mechanical loading (e.g., weight bearing, walking, running) may regulate new blood vessel formation, which is critical for normal bone homeostasis and regeneration. A better understanding of the signaling pathways contributing to "osteo-angio" crosstalk may reveal important new pharmacological targets to prevent and treat osteoporosis, disuse bone loss, and traumatic bone fracture.
The following have contributed to this page: Dr Alesha B Castillo
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