Micelle-to-vesicle transformation as the lights go out
What is it about?
We have synthesized aqueous solutions of polymer nanoparticles (26nm radius) whose structure changes when a chemical (thiophenol) is added. The nanoparticles are initially solid spheres (micelles), but transition to much larger (56nm radius) hollow nanoparticles (vesicles). At the same time the particles also switch from being brightly fluorescent to being non-fluorescent (due to alteration of the dithiomaleimide fluorophore), so the structural change is detectable by fluorescence measurements.
Why is it important?
The study of nanoparticles that can change their structures in response to a chemical or physical stimulus is a huge and exciting field, as these materials have been proposed to be ideal for targeted delivery of drugs to specific areas within the body (eg tumors). However it is often difficult to detect these structural changes within the body (as opposed to in the test tube). This work shows that structural changes can be coupled to changes in fluorescence, which is easier to measure in tissue.
The following have contributed to this page: Dr Mathew Robin and Dr Anaïs Pitto-Barry
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