What is it about?
Analogues of epibatidine, a natural compound isolated from the skin of a frog, have been synthesized. The side chain of the natural compound was moved one carbon atom on the azabicyclic skeleton. Although the compounds were active in vitro, the in vivo activity in rats are low due to a low bio-availability.
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Why is it important?
The epibatidine analogues prove that the design of the molecules are valuable, however further work needs to be done to improve the bio-availability of the compounds.
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This page is a summary of: Synthesis of 1-substituted epibatidine analogues and theirin vitroandin vivoevaluation as α4β2nicotinic acetylcholine receptor ligands, RSC Advances, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c3ra44379e.
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