What is it about?
The fabrication of silica by acid hydrolysis os TEOS in presence of CuCl2 affords the Cu/SiO2 composite with heterogeneous recoverable and recyclable Lewis acid catalyst. Its use in the Huisgen [3+2] cycloaddition allowed the preparation of heterocyclic triazoles which have been applied in the formation of linkers for the melecular hybridization process applied in medicinal chemistry.
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Why is it important?
The importance of the Cu / SiO2 nanocomposite material is due not only to its effectiveness as a catalyst in this reaction, but also to its environmentally compatible characteristics such as recoverability and recyclability. Once the metallic species is trapped inside the silica matrix, the metal is not lost to the environment and can be easily isolated by simple filtration and reused in the next reaction.
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This page is a summary of: Recoverable Cu/SiO2 composite-catalysed click synthesis of 1,2,3-triazoles in water media, New Journal of Chemistry, January 2014, Royal Society of Chemistry, DOI: 10.1039/c3nj01167d.
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