Oxidation of anticancer Pt(ii) complexes with monodentate phosphane ligands: towards stable but active Pt(iv) prodrugs

María Ángeles Medrano, Amparo Álvarez-Valdés, Josefina Perles, Julio Lloret-Fillol, Sandra Muñoz-Galván, Amancio Carnero, Carmen Navarro-Ranninger, Adoración G. Quiroga
  • Chemical Communications, January 2013, Royal Society of Chemistry
  • DOI: 10.1039/c3cc38416k

anticancer non traditional drugs

What is it about?

novel platinum complexes with improved features for better uptaking and pharmacology.

Why is it important?

the complexes structure bears different ligands modulating their properties, in particular the redox potential.

Perspectives

Dr ADORACION GOMEZ QUIROGA (Author)
Universidad Autonoma de Madrid

trans Pt(IV) complexes with aliphatic amines are more reactive than the parent Pt(IV) complexes and they represent a good approach on teh activation of these drugs.

The following have contributed to this page: Dr ADORACION GOMEZ QUIROGA