Methoxy poly(ethylene glycol)-block-polycaprolactone copolymer: formulation and optimization by experimental design; determination of diblock molar mass by multivariate regression analysis of 1H NMR spectra

Mohammad Reza Khanmohammadi, Mohammad Hossein Ahmadi Azqhandi, Bahman Vasheghani Farahani, Reza Najafipour
  • Analytical Methods, January 2013, Royal Society of Chemistry
  • DOI: 10.1039/c3ay26561g

PEG-b-PCL copolymer: formulation and optimization by DOE; determination of Mn by multivariate regres

What is it about?

in this work, we couple NMR spectra with chemometrics for firstly time.

Why is it important?

NMR is not suitable for determination of Mn for high molar mass PEG–PCL copolymers. Thus, the information that can be derived from NMR spectra is restricted because of broad and overlapping signals, poor solubility of polymers or non-availability of suitable solvents. NMR coupled with partial least squares (PLS) regression is applied to determine the Mn of MePEC in the present study.

The following have contributed to this page: Mohammad Hossein Ahmadi Azqhandi