Combined α,α-dialkylprolinol ether/Brønsted acid promotes Mannich reactions of aldehydes with unactivated imines. An entry to anti-configured propargylic amino alcohols

Enrique Gómez-Bengoa, Jacqueline Jiménez, Irati Lapuerta, Antonia Mielgo, Mikel Oiarbide, Itziar Otazo, Irene Velilla, Silvia Vera, Claudio Palomo
  • Chemical Science, January 2012, Royal Society of Chemistry
  • DOI: 10.1039/c2sc20590d