Bismuth(iii) triflate promoted intramolecular hydroamination of unactivated alkenyl sulfonamides in the preparation of pyrrolidines

František Mathia, Peter Szolcsányi
  • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry
  • DOI: 10.1039/c2ob07064b

Efficient and atom-economical aminocyclisation

What is it about?

The novel synthetic method offers an easy and reliable way to access the 5-membered nitrogen-containing cyclic molecules. These are common substructures in many naturally containing alkaloids with wide range of useful biological activities.

Why is it important?

The noteworthy feature of this useful chemical transformation is its technical simplicity and experimental robustness.

The following have contributed to this page: Peter Szolcsanyi