A label-free electrical detection of exosomal microRNAs using microelectrode arrayTatsuro Goda, Kozue Masuno, Junko Nishida, Nobuyoshi Kosaka, Takahiro Ochiya, Akira Matsumoto, Yuji Miyahara
- Chemical Communications, January 2012, Royal Society of Chemistry
- DOI: 10.1039/c2cc36111f
What is it about?
We report a method for detecting microRNAs encapsulated in exosomes using a microelectrode array in semiconductor-based potentiometry after RT-PCR. The inherent miniaturization of the electrical biosensor meets requirements for massively parallel analysis of circulating microRNA as a noninvasive biomarker.