Highlighting a need to distinguish cell cycle signatures from cellular responses to chemotherapeutics in SR-FTIR spectroscopy

C. Hughes, M. D. Brown, F. J. Ball, G. Monjardez, N. W. Clarke, K. R. Flower, P. Gardner
  • The Analyst, January 2012, Royal Society of Chemistry
  • DOI: 10.1039/c2an35633c

Infrared spectra of drug treated cells- (cell cycle or drug induced changes)

What is it about?

Infrared spectroscopy can be used to monitor drug induced changes in cells, but spectra also change due to the cell cycle. These two changes are often difficult to separate. This work shows how this has been achieved.

Why is it important?

Screening for new drugs is a very expensive business so any technique that can do this quickly and efficiently is of great value. Infrared spectroscopy is potentially an new method that can be used. There is much work to be done however, in understanding all the changes observed in the infrared spectra. In particular separating cell cycle affects from those induced by the drug. This work will help develop this method.

The following have contributed to this page: Peter Gardner