Gold-catalysed rearrangement of O-vinyl oximes for the synthesis of highly substituted pyrroles

Simbarashe Ngwerume, Jason E. Camp
  • Chemical Communications, January 2011, Royal Society of Chemistry
  • DOI: 10.1039/c0cc04372a

Multifaceted Catalysis Approach to Pyrrole Synthesis

What is it about?

By taking advantage of a metals ability to catalyse multiple mechanistically distinct processes, multifaceted catalysis, this work enable to direct synthesis of important compounds in a clean and efficient manner.

Why is it important?

First multifaceted catalysis approach to the regioselective synthesis of highly substituted pyrroles from oximes and activated alkynes. This mild and flexible method takes advantage of a gold catalysts ability to activate multiple steps of the process, thus utilising the metal more efficiently.

The following have contributed to this page: Dr Jason Camp and Jason E Camp