A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKaand binding affinity and evidence for intermolecular C–F⋯CN interactions

Jacob Olsen, Paul Seiler, Björn Wagner, Holger Fischer, Thomas Tschopp, Ulrike Obst-Sander, David W. Banner, Manfred Kansy, Klaus Müller, François Diederich
  • Organic & Biomolecular Chemistry, January 2004, Royal Society of Chemistry
  • DOI: 10.1039/b402515f

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http://dx.doi.org/10.1039/b402515f

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