What is it about?
This work describes the interaction between two different networks of intermediate filaments, that might be necessary for keratinocyte migration either in normal skin during wound repair or morphogenetic movements during development, and in Epithelial-Mesenchymal Transition associated to the transformed phenotype
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Why is it important?
The paper describes an interaction that previously was not considered since current knowledge excludes such type of keratin-vimentin association
Perspectives
It may help to explain the cytoskeletal rearrangements necessary for epithelial cell migration
Dr Federico Castro-Munozledo
Centro de Investigación y de Estudios Avanzados del IPN
Read the Original
This page is a summary of: Epithelial cell migration requires the interaction between the vimentin and keratin intermediate filaments, Scientific Reports, April 2016, Nature,
DOI: 10.1038/srep24389.
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