Understanding the fracture of pharmaceutical powder particles

What is it about?

Mannitol is an essential excipient employed in orally disintegrating tablets. The aim of this study was to assess the fracture behaviour of crystalline mannitol in relation to the energy input during direct compression, utilising ball milling as the method of energy input, whilst assessing tablet characteristics of post-milled powders. It is concluded that particle size reduction is a pragmatic strategy to overcome the current limitation of mannitol fragmentation and provide improvements in tablet properties.

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