What is it about?
Recent decades have seen several complimentary biophysics tools emerge to study single protein macro-molecules. Most of these techniques use glass as a specimen support. The atomic force microscope, a vital tool in biophysics suited to study proteins in their near native environments, uses mica as a specimen support, as it is known for its extreme flatness and ease of use. Here we optimized glass as a specimen support for atomic force microscopy. This enables the combination of other single molecule techniques with atomic force microscopy to study the same protein macromolecular system in unison.
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Why is it important?
This work opens the door for combining high resolution biological AFM with other powerful complementary single molecule techniques that require glass as a specimen support.
Perspectives
I hope this article will help other scientists to study the same molecule or macromolecular system using multiple amazing single molecule techniques at the same time
Nagaraju Chada
Johns Hopkins University
Read the Original
This page is a summary of: Glass is a Viable Substrate for Precision Force Microscopy of Membrane Proteins, Scientific Reports, July 2015, Springer Science + Business Media,
DOI: 10.1038/srep12550.
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