What is it about?
Comparing the effect of genetic and environmental factors of hyperuricemia.
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Why is it important?
Genetic factor, two dysfunctional variants of ABCG2, has stronger effect than environmental factors (obesity, drinking, aging).
Perspectives
Urate metabolism is changed between monkeys and humans. So, genetic effects is still strong in human for urate handling. Of course, their background lifestyles are still essential for the progression of hyperuricemia, and therefore a genetic factor would affect as "the last one push" for hyperuricemia and gout progression.
Dr. Akiyoshi Nakayama
aknak@ndmc.ac.jp
Read the Original
This page is a summary of: Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors, Scientific Reports, June 2014, Nature,
DOI: 10.1038/srep05227.
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