What is it about?
The study clarified the effects and the mechanism of diosgenin, a famous plant-derived steroidal sapogenin, on memory deficits in Alzheimer's disease (AD) model mice. Diosgenin-treated AD mice exhibited significantly improved memory. Diosgenin treatment significantly reduced amyloid plaques and neurofibrillary tangles in the brain. Degenerated axons and presynaptic terminals were also significantly reduced by diosgenin treatment. The 1,25D₃-membrane-associated, rapid response steroid-binding protein (1,25D₃-MARRS) was shown to be a receptor of diosgenin. This is the first study to demonstrate that the exogenous stimulator diosgenin activates the 1,25D₃-MARRS pathway, which may be a very critical signaling target for anti-AD therapy.
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Why is it important?
Diosgenin can repair axonal degeneration in Alzheimer's disease brain not only reduce Amyloid plaques. This medication is promising for fundamental therapy of dementia.
Perspectives
This is the first publication about Diosgenin as an anti-dementia drug using Alzheimer's disease model mice.
Chihiro Tohda
Read the Original
This page is a summary of: Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice, Scientific Reports, July 2012, Springer Science + Business Media,
DOI: 10.1038/srep00535.
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