What is it about?
Genetic variants in circadian clock genes were suggested to play a role in the pathogenesis of the winter type of seasonal affective disorder, and affect the chronotype or preference to the daily activities.
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Why is it important?
This is the first report to show that genetic variants in circadian clock genes associate with seasonal affective disorder and with chronotype.
Perspectives
Abnormalities in functions of the circadian clock often characterize patients with mood disorders. Thus, circadian clock genes are targets of interest in these patients. The data provided the first evidence for involvement of circadian clock genes in mood disorders.
Professor Timo Partonen
National Institute for Health and Welfare
Read the Original
This page is a summary of: Circadian Clock-Related Polymorphisms in Seasonal Affective Disorder and their Relevance to Diurnal Preference, Neuropsychopharmacology, December 2002, Springer Science + Business Media,
DOI: 10.1038/sj.npp.1300121.
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