PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile

What is it about?

Helper-dependent adenoviral vectors deleted of all viral coding sequences, are attractive vectors for gene therapy which can efficiently transduce a wide variety of cell types and promote long-term transgene expression. However, their use is limited by the host response against capsid proteins. In this report, authors show that PEGylation of helper-dependent adenoviral vectors dampen the innate immune response against capsid proteins and eliminate any remaining toxicity associated with systemic administration of the virus. Therefore, PEGylation of helper-dependent adenoviral vectors may be appropriate for their safe and efficient use in the clinic.

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Photo by Fusion Medical Animation on Unsplash

Photo by Fusion Medical Animation on Unsplash