What is it about?
Here we have discovered the genetic origin and metabolic pathway of exhaled breath isoprene in humans. With that we present the first breath volatile organic biomarker with confirmed endogenous origin.
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Why is it important?
Our findings will translate isoprene as a non-invasive breath VOC biomarker for various applications in clinical sciences.
Perspectives
Knowledge of accurate metabolic origin is indispensable for valid clinical interpretation of any endogenous biomarker. Apart from isoprene, our breath contains many potentially endogenous VOCs and their sources are yet uncertain. We cannot speculate on clinical outcomes based on putative substance origins as such practice inevitably is prone to error.
Dr. Pritam Sukul
University Medicine Rostock, Germany
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This page is a summary of: Origin of breath isoprene in humans is revealed via multi-omic investigations, Communications Biology, September 2023, Springer Science + Business Media,
DOI: 10.1038/s42003-023-05384-y.
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