What is it about?
Using ASL MRI to identify blood brain barrier leak acutely in minor traumatic brain injury in young athletes with associated cognitive impairment and repair of the leak upon clinical recovery.
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Why is it important?
This method has potential as a diagnostic tool identifying acute brain injury and an objective measure correlating with recovery.
Perspectives
This study sheds further light on the importance of the blood brain barrier integrity for normal cognition. It also points to the ability of young brains to repair BBB leak that fails with aging. Why is that? What are the pathways of BBB repair and how once determined can that be leveraged to treat preclinical neurodegenerative disease (where they fail)?
Associate Professor of Neurology Charles Joseph
Liberty University College of Osteopathic Medicine
Read the Original
This page is a summary of: Identifying delay in glymphatic clearance of labeled protons post-acute head trauma utilizing 3D ASL MRI (arterial spin labeling): a pilot study, Scientific Reports, March 2024, Springer Science + Business Media,
DOI: 10.1038/s41598-024-56236-6.
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