What is it about?
This well-described model of HCC was utilized to study the mechanism of the anti-cancer action of GSE during the early stages of hepatocellular tumor promotion by evaluating its antioxidant, pro-apoptotic, anti-proliferative, histone deacetylase (HDAC) inhibitory and anti-inflammatory effects. In addition, HepG2 cells were used here to shed more light on the mechanism by which GSE exerts its anticancer activity against liver cancer in vitro.
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Why is it important?
This study investigated the protective effects of the herbal drug, GSE, on the early hepatic pre-neoplastic events, using a two-stage carcinogenic model combining DEN and 2AAF. GSE’s anti-oxidative stress, anti-inflammatory, anti-proliferative, and pro-apoptotic effects are well-documented here both in vitro and in vivo.
Perspectives
The data presented here showed that GSE dramatically inhibited FAH formation in livers of DEN-2AAF-treated rats. GSE’s effects were associated with induced apoptosis, reduced cell proliferation, decreased oxidative stress and down regulation of HDAC activity and inflammation makers, such as COX-2, iNOS, NF-κB-p65 and p-TNFR1 expressions. Those effects are schematically depicted in Fig. 8, which incorporates our data into a model showing a possible mechanism of the anti-cancer protective effect of GSE by promoting apoptosis, inhibiting cell proliferation and blocking inflammation in hepatocarcinomas.
Dr Alaaeldin A Hamza
National Organization for Drug Control and Research
Read the Original
This page is a summary of: Molecular characterization of the grape seeds extract’s effect against chemically induced liver cancer: In vivo and in vitro analyses, Scientific Reports, January 2018, Springer Science + Business Media,
DOI: 10.1038/s41598-018-19492-x.
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