What is it about?
Does each step of replicative aging change stress resistance profile of microbial cell? We challenged this question using asymmetrically dividing baker's yeasts. Surprisingly, we found that the levels of several stress-response proteins do not change with mother cell age despite significant mother-bud asymmetry for these proteins. Thus replicative age contribution to the yeast individual heterogeneity are comparatively low.
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Why is it important?
Manifestation of replicative aging in yeast mother cells starts after production of 15-20 buds. However, the proportion of such old cells in population is extremely low. Therefore, smaller changes in younger mother cell age cohorts can impact the performance of yeast population to much greater extent. In our work we studied age-dependent difference in stress-response protein levels for most abundant yeast mother cells age cohorts.
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This page is a summary of: The contribution of Saccharomyces cerevisiae replicative age to the variations in the levels of Trx2p, Pdr5p, Can1p and Idh isoforms, Scientific Reports, October 2017, Nature,
DOI: 10.1038/s41598-017-13576-w.
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