What is it about?
Mutation of the transmembrane helix number 11 amino acid residues to alanine and finding out its importance in the Na+/H+ antiporter activity via salt tolerance experiments.
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Why is it important?
It identified the amino acids in the above mention segment and direct towards a possibility to use them to increase salt resistance in yeast.
Perspectives
The work is a rigorous approach to characterize the residues one by one and provides an explanation of its role based on the existing Na+/H+ structures.
Debajyoti Dutta
University of Alberta
Read the Original
This page is a summary of: Transmembrane Segment XI of the Na+/H+ Antiporter of S. pombe is a Critical Part of the Ion Translocation Pore, Scientific Reports, October 2017, Springer Science + Business Media,
DOI: 10.1038/s41598-017-12701-z.
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