What is it about?
We show that damaged blood vessels regulate their own repair by educating specialized inflammatory cells called macrophages. This cross-talk is mediated by factors expressed in endothelial cells, which control macrophage maturation into repair cells.
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Why is it important?
The restoration of blood flow after clogging of an artery is essential for the regeneration of vital organs, such as the heart, muscles or the brain. The interruption of blood flow (so-called ischemia) causes an inflammatory response that is intended to restore perfusion and organ function yet that response often aggravates tissue damage. We show how blood vessels can turn inflammation into a helpful response.
Perspectives
Cross-talk between blood vessels and macrophages novel regulator of inflammation and tissue regeneration
Florian Limbourg
Medizinische Hochschule Hannover
Read the Original
This page is a summary of: Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia, Nature Communications, October 2017, Nature,
DOI: 10.1038/s41467-017-00953-2.
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