What is it about?
Fundamental medication of Alzheimer's disease via repairing axons and behind mechanism
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Why is it important?
Damaged axons successfully extended to their native projecting area in mouse models of Alzheimer's disease (5XFAD) by administration of an axonal regenerative agent, Diosgenin. In vivo transcriptome analysis identified Secreted Protein Acidic and Rich in Cysteine (SPARC) as a responsible and critical molecule for axonal repairing. Diosgenin administration as well as SPARC over expression similarly recovered memory function and axonal projection from the hippocampus to the prefrontal cortex.
Perspectives
These findings suggest that SPARC-driven axonal growth in the brain may be a promising therapeutic strategy for AD and other neurodegenerative diseases.
Chihiro Tohda
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This page is a summary of: Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice, Molecular Psychiatry, April 2023, Springer Science + Business Media,
DOI: 10.1038/s41380-023-02052-9.
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