What is it about?
We evaluated the relationship between polymorphisms in the glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 genes and prostate cancer (PCa). PCR-restriction fragment length polymorphism assay was used to genotype the GSTM1, GSTT1, and GSTP1 polymorphisms in 168 PCa cases and 336 frequency matched controls.
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Why is it important?
Prostate cancer (PCa) is the most common malignancy among men in industrialized countries and with a worldwide incidence of 25.3 per 100 000, PCa is the second most common cancer in men.1 In contrast to other Asian populations, with a detection rate of 3.6–3.8%, the incidence of PCa in Iran is quite high.4,5 It is well documented that genetic factors may account for as much as 42% of the PCa risk.6 There are no consistent patterns of single chromosomal abnormalities in PCa; instead, the entire genome is apparently involved in prostatic carcinogenesis.
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This page is a summary of: Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran, Prostate Cancer and Prostatic Diseases, January 2011, Springer Science + Business Media, DOI: 10.1038/pcan.2010.54.
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