What is it about?

The article provides a quantitative and physical foundation for understanding cell cycle entry, the dysregulation of which results in cancer development.

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Why is it important?

1. It challenges the textbook view of fundamental mechanism underlying cell cycle control and is is a paradigm shift. 2. It explored the chemical kinetics of Rb/E2F network activation to quantitatively define the control logic of cell cycle entry. 3. The methodology will apply to the study of other gene regulatory networks.

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This page is a summary of: Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control, Nature Communications, September 2014, Nature,
DOI: 10.1038/ncomms5750.
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