What is it about?
Dysfunction of urate exporter ABCG2 increases renal urate excretion.
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Why is it important?
ABCG2 dysfunction revealed to be essential for intestinal urate excretion. A novel concept of classification of hyperuricemia and gout is proposed in this report.
Perspectives
"Urate overproduction" was revealed to have been misunderstood. Now, it is proposed to be renamed as "urate overload" which includes genuine "urate overproduction" and "extra-renal urate underexcretion".
Dr. Akiyoshi Nakayama
aknak@ndmc.ac.jp
Read the Original
This page is a summary of: Decreased extra-renal urate excretion is a common cause of hyperuricemia, Nature Communications, April 2012, Nature,
DOI: 10.1038/ncomms1756.
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