Development of new antibiotics for treatment of drug resistant Tuberculosis
What is it about?
We use an old class of drugs (Beta lactams) and show their inhibition of L,D-transpeptidase which is important in mycobacteria. We performed mechanistic characterization of compounds and designed and tested some new potent antibacterials.
Why is it important?
TB treatment needs new drugs and yet beta lactams have not been widely used to treat this disease. We provide a better understanding of how the bet-lactams function against the enzyme L,D-transpeptidase. We solved many crystal structures and tested carbapems in vivo. We also designed new compounds. We also identified L,D-transpeptidases in ESKAPE pathogens.
The following have contributed to this page: Dr Sean Ekins and Dr Pankaj Kumar