What is it about?
Detailed chromosome measurements revealed that chromosomes compact maximally in the phase of cell division called anaphase, not in metaphase, as has been the “textbook” model. This step of anaphase “super-compaction” happens by a lengthwise shortening that starts only after segregation of the sister chromatids is complete, and required dynamic microtubules and aurora B kinase
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Why is it important?
Anaphase super compaction removes chromatid arms from the cleavage plane, preventing chromosome damage and miss-segregation. It also helps re-establish a normal nuclear morphology and architecture for interphase.
Perspectives
This paper presents the discovery of mechanism that helps to safeguard the integrity and architecture of the genome during and after cell division. The consequences of chromosome damage, faulty chromosome segregation and faulty re-establishment of the nuclear architecture can be deadly and range from aneuploidy to cancer.
Dr Felipe Mora-Bermúdez
MPI-CBG
Read the Original
This page is a summary of: Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase, Nature, June 2007, Nature,
DOI: 10.1038/ncb1606.
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