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By swapping key residues from C15orf27, a molecule that is NOT a proton channel, into the human proton channel hHv1, we identify Asp112 in the middle of the S1 domain as the selectivity filter. Surprisingly, most mutants are anion selective! Only D112E remains proton specific. Even more astoundingly, D112H conducts Cl-! Mutant channels appear to be permeable to OH-
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This page is a summary of: Aspartate 112 is the selectivity filter of the human voltage-gated proton channel, Nature, October 2011, Springer Science + Business Media,
DOI: 10.1038/nature10557.
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