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The voltage dependence of NADPH oxidase activity (electron current) is determined. Enzyme activity is abolished by extreme depolarization of the cell membrane. Unexpectedly strong rectification of the electron current-voltage curve resolves the decade-long mystery of apparent discrepancies between the [Zn2+] that inhibits proton channels vs. that which inhibits NADPH oxidase activity (superoxide production).
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This page is a summary of: The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels, Nature, April 2003, Springer Science + Business Media,
DOI: 10.1038/nature01523.
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